युएनडीओको पहिलो बैठक, ६ जना मनोनित, विभिन्न थप निर्णय

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नेपाल सरकारको परराष्ट्र मन्त्रालयमा दर्ता भएको United Nepali Diaspora Organization/युनाइटेड नेपाली डायस्पोरा अर्गनाइजेशन ((UNDO/यूएनडीओ) को डिसेम्बर ३०, २०२४ का दिन अध्यक्ष सोनाम लाममाको अध्यक्षतामा पहिलो बैठक बसेर विभिन्न निणर्यहरु गरेको छ। 

बैठकले सँस्थाको बिधान अनुसार सँस्थाका लागि योग्य, प्रतिबद्ध र प्रेरणादायी ६ जना व्यक्तित्वहरूलाई केन्द्रिय कार्यकारी सदस्यका रूपमा मनोनित गरेको छ। 

मनोनितहरु यस प्रकार हुनुहुन्छ:  

महिलातर्फ

  1. Indira Roka – Australia
  2. Sambriddi Gurung – UK
  3. Sundari Lama – Spain

पुरुषतर्फ 

  1. Ershad Ahmed – Australia
  2. Krishna Sanjel KC – USA
  3. Shamim Anwar – Australia

यसका साथै बैठकले आगामी योजना, सँस्था बिस्तार, श्रोत परिचालन र विकास, सँस्थाका आन्तरिक लगायत थुप्रै एजेण्डाहरुमा छलफल र निर्णय गरेको कुरा महासचिव कुशल केसीले जानकारी दिनु भएको छ।

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  6. It binds to the receptors of another hormone, ghrelin, which
    also stimulates the pituitary gland to launch development hormone
    (1). The peptide consists of 44 amino acids with a modified construction that gives
    it better stability and effectiveness in comparability with pure GHRH.
    Unlike direct human growth hormone (HGH) supplementation, tesamorelin works by encouraging your body to provide more
    of its own growth hormone. The World Anti-Doping Company (WADA) prohibits its use in aggressive sports due to its GH-stimulating results.
    Medical trials have predominantly centered on Tesamorelin’s efficacy in reducing visceral adipose tissue
    (VAT) in HIV-infected sufferers with lipodystrophy,
    a situation characterised by irregular fat distribution. Studies have demonstrated vital reductions in VAT,
    along with improvements in associated metabolic parameters.

    The drug’s capacity to lower VAT, a risk issue for cardiovascular ailments, with out
    considerably altering subcutaneous fats makes it
    a valuable treatment for lipodystrophy in HIV patients.

    Keep Away From unverified on-line sources to prevent counterfeit merchandise and
    potential well being risks. Consulting a healthcare professional is important to determine the finest option in your specific needs.
    Research subjects should seek medical attention instantly in the
    event that they experience any severe allergic reactions similar to itching, swelling, rashes, problem breathing, or hives.

    Secretagogues activate receptors within the brain, signaling the pituitary gland to launch GH into the bloodstream.
    Increasing GH levels can improve muscle progress, fats
    loss, and overall vitality. It mimics your body’s
    personal development hormone–releasing hormone (GHRH), gently
    signaling the pituitary gland to launch GH in a pure, balanced
    rhythm. We like Sermorelin as a outcome of it enhances
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    Injectable peptides like sermorelin, ipamorelin, and tesamorelin can replenish declining development hormone ranges,
    making it simpler to shed weight, construct muscle,
    and achieve power. The main variations between them are how they enhance progress hormone, their price, and some side effects.

    In Distinction To GHRH analogs, Ipamorelin is a GH-releasing
    peptide (GHRP) that binds to ghrelin receptors, stimulating GH release whereas minimizing cortisol and prolactin will increase (Svensson).
    Sermorelin is an artificial analog of GHRH, consisting of the primary 29 amino acids of naturally
    occurring GHRH. It stimulates pituitary GH release, aligning with pure physiological GH pulsatility (Sigalos
    & Pastuszak). Sermorelin was first developed by pharmaceutical firm
    EMD Serono as the shortest fragment of GHRH’s 44 amino acid sequence that’s nonetheless totally functional and stimulates GH
    release [3]. Its shorter structure aside, sermorelin has
    been proven to have a similar half-life to GHRH [4].
    Physiological GHRH secretion is what primarily regulates the synthesis of progress
    hormone (GH) in wholesome individuals [2]. The process of fats burning is accompanied by a rise in muscle mass, resulting in a extra toned and outlined appearance.

    Prescriptions ensure that these peptides are sourced from FDA-regulated compounding pharmacies, guaranteeing their security, sterility, and quality.
    Peptides from unregulated web sites carry risks of contamination, improper
    dosing, and substandard manufacturing practices,
    which can lead to severe well being points. Sure, a mix of Tesamorelin and Ipamorelin is feasible and is commonly used to stimulate the pituitary gland to supply and secrete development hormone.
    As a growth hormone-releasing peptide, ipamorelin can also boost GH and IGF-1 ranges, enhancing sexual operate in men and women.
    In two Phase three clinical trials and their pooled analyses, tesamorelin was proven to significantly decrease waist circumference and visceral adipose tissue (VAT) following 26
    weeks of remedy. It works by stimulating the pituitary gland,
    secreting and activating development hormone (GH).
    It works by growing the molecule nitric oxide, stimulating longer and more durable erections in males.
    Most importantly, these outcomes indicate that ghrelin has the
    potential to amplify dopamine signaling selectively in neurons that coexpress D1R and GHS-R.
    The enhance in ghrelin additionally boosts the mind
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    When stacked with Tesamorelin, BPC-157 can enhance injury
    recovery and intestine health while Tesamorelin drives metabolic and muscular adaptations.
    ▶ IpamorelinA delicate GHRP (Growth Hormone Releasing Peptide),
    Ipamorelin can complement Tesamorelin’s results by stimulating further GH pulses without inflicting elevated cortisol or prolactin.
    This makes it a safe, synergistic stack to boost fat burning and sleep recovery.

    Pairing Tesamorelin with specific dietary supplements can improve its fat-loss and muscle-preserving effects, whereas additionally supporting
    hormonal stability, recovery, and sleep.
    For instance, stacking Ipamorelin with CJC-1295 provides the most effective of both worlds—extended GH elevation with precise,
    focused pulses. At Peptide Hub, we’re dedicated to delivering precision and high quality with every order.
    Our team’s expertise and rigorous requirements ensure that
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    As part of your subscription and as medically indicated, physicians prescribe drugs,
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    Co-administration of those peptides doubtless produces significant
    GH peaks while preserving the pulsatile GH launch pattern, doubtlessly leading to more
    vital modifications in GH levels than Sermorelin alone.
    Sermorelin, ipamorelin, and tesamorelin are self-injected subcutaneously (right beneath
    the skin). Dosage can differ, but most protocols
    advocate daily injections for all three peptides.
    This article reviews the mechanistic variations, printed trial outcomes, and comparative purposes of
    tesamorelin, sermorelin, and ipamorelin. All data provided is intended strictly for educational and investigational purposes.

    The compounds discussed are designated for laboratory research use only and aren’t approved for human consumption or
    medical application. At All Times inform your health care supplier about any
    prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products,
    and other supplements you would possibly be using.
    When you enter your mid-thirties, your body makes less development hormone (GH), a key participant
    in muscle progress, fat metabolism, and appetite regulation (1).
    Tesamorelin injection is used to decrease the amount of extra fat
    in the stomach area in adults with human immunodeficiency virus (HIV) who
    have lipodystrophy (increased physique fat in certain areas of the body).
    Tesamorelin injection is in a category of medicines called
    human development hormone-releasing factor (GRF) analogs.

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  7. All three peptides alter physique composition, favoring lean physique
    mass by burning white fat and rising muscle and bone
    mass. The question is whether Sermorelin supplies extra physique composition change by itself or
    if Ipamorelin and Tesamorelin collectively promote more lean physique mass.
    Comparable to sermorelin, ipamorelin indicators
    the pituitary gland to launch extra development hormone.

    Ipamorelin is a selective ghrelin receptor agonist (GHSR1a),
    belonging to the expansion hormone secretagogue (GHRP) class.

    In Contrast To earlier GHRPs, ipamorelin demonstrates
    excessive selectivity for GH release, with minimal exercise on ACTH
    or cortisol. Research in healthy volunteers
    confirmed dose-dependent GH increases with a clean pharmacokinetic/pharmacodynamic (PK/PD) profile (PubMed).

    Studies recommend that its ability to boost GH manufacturing might play a job in bettering muscle mass, lowering fat accumulation, and boosting
    overall vitality. Peptides are brief chains of amino acids that play an important function in cellular operate and restore.
    At Circulate Wellness, we provide customized peptide protocols to help athletic performance, muscle recovery, and cognitive
    efficiency.
    Tesamorelin mimics the motion of an endogenous hormone within the body often recognized as
    growth hormone-releasing hormone (GHRH). It binds with the expansion hormone-releasing hormone receptors (GHRHr) positioned within the anterior pituitary gland.
    This triggers the discharge of progress hormone
    (GH) which binds with numerous cells like myocytes, hepatocytes, adipocytes, and
    osteoblasts. Monitoring hormone levels and consulting a healthcare supplier frequently might help mitigate these dangers and ensure the correct stability of growth hormone in the body.

    This mimics the body’s pure rhythm and helps
    preserve normal feedback regulation between GH
    and IGF-1 ranges (Falutz et al.). Possession and not utilizing a prescription can carry
    legal penalties depending on jurisdiction. ▶ Longevity-focused usersPeptide therapy, together with Tesamorelin, is often a half of
    anti-aging and well being optimization stacks because of
    its potential to help sleep, cognitive clarity, and energy levels.
    ▶ Males and girls over 35GH ranges decline
    with age, contributing to fat achieve, slower recovery,
    and poor sleep. Tesamorelin can restore GH to more youthful
    levels—improving physique composition, restoration, and skin tone.
    ▶ IGF-1 LR3Advanced customers might discover IGF-1 LR3 post-Tesamorelin to extend the benefits of
    increased GH and IGF-1 ranges. However, stacking both requires a well-planned cycle, as IGF-1 is a
    potent progress factor that will increase systemic effects like muscle progress and insulin sensitivity.

    HGH peptides stimulate the natural production of Human Growth Hormone
    (HGH) by activating the pituitary gland. This helps
    with growth, metabolism, and the maintenance of bodily functions similar to fat loss and muscle development.
    Tesamorelin is a GHRH analog that stimulates GH launch and
    IGF-1 production, with a notable impact on visceral fats metabolism (Wang &
    Tomlinson). Analysis suggests it may reduce fats accumulation whereas preserving lean muscle mass.
    This artificial peptide has a similar structure to the endogenous development hormone-releasing hormone
    (GHRH) and acts by mimicking its actions within the body. Analysis shows Tesamorelin decreases muscle fats content material and will increase muscle area in adults with HIV,
    supporting the concept it will increase muscle mass.

    There is good reason to believe that it has ample anti-aging results even when they don’t fairly rise to the extent of Sermorelin. Ipamorelin, a synthetic peptide, acts as a development hormone secretagogue
    by stimulating the pituitary gland to extend natural
    development hormone production. This process leads to improved muscle growth, fats metabolism,
    and general physique composition.
    Sermorelin’s proposed clinical use in hypogonadal males and males with
    SH is “lean mass gain” [5]. Sermorelin and Tesamorelin belong to the category of peptide hormones that stimulate the production and release of progress hormone in the body.
    Whereas Sermorelin works by rising the pure production of progress hormone in the pituitary gland,
    Tesamorelin acts directly on the hypothalamus to reinforce GH secretion. Tesamorelin is a development hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to supply extra development hormone (GH).

    This leads to elevated ranges of insulin-like growth issue 1 (IGF-1), which is crucial for fat
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